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                <h1 class="article-title" itemprop="name">Submit New</h1>
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                <p>The rules of Submit New</p>
<h1 id="Work-flow" class="article-heading"><a href="#Work-flow" class="headerlink" title="Work flow"></a>Work flow<a class="article-anchor" href="#Work-flow" aria-hidden="true"></a></h1><p>First of all, you need to select a three-dimensional genome related disease, and accumulate a certain amount of knowledge of the disease (choosing a three-dimensional genome related diseases from paper reading is recommended, and use workflow to describe the disease.)</p>
<h3 id="Diseases" class="article-heading"><a href="#Diseases" class="headerlink" title="Diseases:"></a>Diseases:<a class="article-anchor" href="#Diseases" aria-hidden="true"></a></h3><p>According to ICD-11, select the related diseases’ name. </p>
<h3 id="Another-name" class="article-heading"><a href="#Another-name" class="headerlink" title="Another name:"></a>Another name:<a class="article-anchor" href="#Another-name" aria-hidden="true"></a></h3><p>According to ICD-11 or ICD-10’s another name.</p>
<h3 id="Short-name" class="article-heading"><a href="#Short-name" class="headerlink" title="Short name:"></a>Short name:<a class="article-anchor" href="#Short-name" aria-hidden="true"></a></h3><p>According to ICD-11 or ICD-10 or OMIM’s short name.</p>
<h3 id="ICD-10-code" class="article-heading"><a href="#ICD-10-code" class="headerlink" title="ICD-10 code:"></a>ICD-10 code:<a class="article-anchor" href="#ICD-10-code" aria-hidden="true"></a></h3><p>Open the ICD-10 website, search the name of the disease, find the code.</p>
<h3 id="ICD-11-code" class="article-heading"><a href="#ICD-11-code" class="headerlink" title="ICD-11 code:"></a>ICD-11 code:<a class="article-anchor" href="#ICD-11-code" aria-hidden="true"></a></h3><p>Open the ICD-10 website, search the name of the disease, find the code.</p>
<h3 id="OMIM-ID" class="article-heading"><a href="#OMIM-ID" class="headerlink" title="OMIM ID:"></a>OMIM ID:<a class="article-anchor" href="#OMIM-ID" aria-hidden="true"></a></h3><p>Open OMIM website, search related diseases and find OMIM corresponding to diseases. </p>
<h3 id="Variation-position" class="article-heading"><a href="#Variation-position" class="headerlink" title="Variation position:"></a>Variation position:<a class="article-anchor" href="#Variation-position" aria-hidden="true"></a></h3><p>Open OMIM website, search related diseases, find mutation’s location.</p>
<h3 id="Ref-genome" class="article-heading"><a href="#Ref-genome" class="headerlink" title="Ref genome:"></a>Ref genome:<a class="article-anchor" href="#Ref-genome" aria-hidden="true"></a></h3><p>Hg19/hg38</p>
<h3 id="Associate-type" class="article-heading"><a href="#Associate-type" class="headerlink" title="Associate type:"></a>Associate type:<a class="article-anchor" href="#Associate-type" aria-hidden="true"></a></h3><p>Understand the related diseases and determine which of the following types of variation occurs:</p>
<ul>
<li>1D: SNP, or only the genome sequence changed;</li>
<li>2D: Only epigenetic modifications (methylation, acetylation, etc.) occurred;</li>
<li>1D &amp; 2D: Both genome sequence and epigenetic modifications changed;</li>
<li>2D &amp; 3D: Epigenetic modification and three-dimensional structure of genome changed;</li>
<li>1D &amp; 2D &amp; 3D: Genome sequence, epigenetic modification and three-dimensional structure of genome changed.</li>
</ul>
<h3 id="Genetic-epigenetic-alteration" class="article-heading"><a href="#Genetic-epigenetic-alteration" class="headerlink" title="Genetic epigenetic alteration:"></a>Genetic epigenetic alteration:<a class="article-anchor" href="#Genetic-epigenetic-alteration" aria-hidden="true"></a></h3><p>If there is any change in epigenetic modification, please write down the type of epigenetic modification.</p>
<h3 id="Type" class="article-heading"><a href="#Type" class="headerlink" title="Type:"></a>Type:<a class="article-anchor" href="#Type" aria-hidden="true"></a></h3><p>Please choose one of cis or trans according to the following introduction about cis and trans:</p>
<ul>
<li><p><code>cis</code>: The change of genome sequence information is the essential cause of disease</p>
</li>
<li><p><code>Trans</code>: the essential reason for diseases is that the structure of three-dimensional genome changes due to regulatory elements or epigenetic modification’s abnormal.</p>
</li>
</ul>
<h3 id="Disease-related-gene：" class="article-heading"><a href="#Disease-related-gene：" class="headerlink" title="Disease related gene："></a>Disease related gene：<a class="article-anchor" href="#Disease-related-gene：" aria-hidden="true"></a></h3><p>Genes in cis and trans, and their related genes (the occurrence of a three-dimensional genome related disease usually involves more than one gene).</p>
<h3 id="Brief-introduction-of-disease-related-gene" class="article-heading"><a href="#Brief-introduction-of-disease-related-gene" class="headerlink" title="Brief introduction of disease related gene:"></a>Brief introduction of disease related gene:<a class="article-anchor" href="#Brief-introduction-of-disease-related-gene" aria-hidden="true"></a></h3><p>Briefly describe the function of this or these genes (or attach a link, it is not clear which website is the introduction of the corresponding gene).</p>
<h3 id="Pathogenesis-mechanism" class="article-heading"><a href="#Pathogenesis-mechanism" class="headerlink" title="Pathogenesis mechanism:"></a>Pathogenesis mechanism:<a class="article-anchor" href="#Pathogenesis-mechanism" aria-hidden="true"></a></h3><p>Briefly describe the mechanism of the disease.</p>
<h3 id="Ref-doi" class="article-heading"><a href="#Ref-doi" class="headerlink" title="Ref doi:"></a>Ref doi:<a class="article-anchor" href="#Ref-doi" aria-hidden="true"></a></h3><p>The format has not been unified.</p>
<h3 id="The-related-topic-mentioned-is-the-study-of-diseases" class="article-heading"><a href="#The-related-topic-mentioned-is-the-study-of-diseases" class="headerlink" title="The related topic mentioned is the study of diseases"></a>The related topic mentioned is the study of diseases<a class="article-anchor" href="#The-related-topic-mentioned-is-the-study-of-diseases" aria-hidden="true"></a></h3><p>In the process of paper reading, record the diseases related to three-dimensional genome, but have not been carefully studied.</p>
<h3 id="Other-perspectives" class="article-heading"><a href="#Other-perspectives" class="headerlink" title="Other perspectives"></a>Other perspectives<a class="article-anchor" href="#Other-perspectives" aria-hidden="true"></a></h3><ul>
<li><code>ICD</code>: international Classification of diseases</li>
<li><code>ICD-10</code>: <a target="_blank" rel="noopener external nofollow noreferrer" href="https://icd.who.int/browse10/2019/en#/Q99.2">https://icd.who.int/browse10/2019/en#/Q99.2</a></li>
<li><code>ICD-11</code>: <a target="_blank" rel="noopener external nofollow noreferrer" href="https://icd.who.int/browse11/l-m/en#/http://id.who.int/icd/entity/2132180242">https://icd.who.int/browse11/l-m/en#/http://id.who.int/icd/entity/2132180242</a></li>
<li><code>OMIM ID</code>: <a target="_blank" rel="noopener external nofollow noreferrer" href="https://www.omim.org/entry/300624">https://www.omim.org/entry/300624</a></li>
</ul>

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              <ol class="toc"><li class="toc-item toc-level-1"><a class="toc-link" href="#Work-flow"><span class="toc-text">Work flow</span></a><ol class="toc-child"><li class="toc-item toc-level-3"><a class="toc-link" href="#Diseases"><span class="toc-text">Diseases:</span></a></li><li class="toc-item toc-level-3"><a class="toc-link" href="#Another-name"><span class="toc-text">Another name:</span></a></li><li class="toc-item toc-level-3"><a class="toc-link" href="#Short-name"><span class="toc-text">Short name:</span></a></li><li class="toc-item toc-level-3"><a class="toc-link" href="#ICD-10-code"><span class="toc-text">ICD-10 code:</span></a></li><li class="toc-item toc-level-3"><a class="toc-link" href="#ICD-11-code"><span class="toc-text">ICD-11 code:</span></a></li><li class="toc-item toc-level-3"><a class="toc-link" href="#OMIM-ID"><span class="toc-text">OMIM ID:</span></a></li><li class="toc-item toc-level-3"><a class="toc-link" href="#Variation-position"><span class="toc-text">Variation position:</span></a></li><li class="toc-item toc-level-3"><a class="toc-link" href="#Ref-genome"><span class="toc-text">Ref genome:</span></a></li><li class="toc-item toc-level-3"><a class="toc-link" href="#Associate-type"><span class="toc-text">Associate type:</span></a></li><li class="toc-item toc-level-3"><a class="toc-link" href="#Genetic-epigenetic-alteration"><span class="toc-text">Genetic epigenetic alteration:</span></a></li><li class="toc-item toc-level-3"><a class="toc-link" href="#Type"><span class="toc-text">Type:</span></a></li><li class="toc-item toc-level-3"><a class="toc-link" href="#Disease-related-gene%EF%BC%9A"><span class="toc-text">Disease related gene：</span></a></li><li class="toc-item toc-level-3"><a class="toc-link" href="#Brief-introduction-of-disease-related-gene"><span class="toc-text">Brief introduction of disease related gene:</span></a></li><li class="toc-item toc-level-3"><a class="toc-link" href="#Pathogenesis-mechanism"><span class="toc-text">Pathogenesis mechanism:</span></a></li><li class="toc-item toc-level-3"><a class="toc-link" href="#Ref-doi"><span class="toc-text">Ref doi:</span></a></li><li class="toc-item toc-level-3"><a class="toc-link" href="#The-related-topic-mentioned-is-the-study-of-diseases"><span class="toc-text">The related topic mentioned is the study of diseases</span></a></li><li class="toc-item toc-level-3"><a class="toc-link" href="#Other-perspectives"><span class="toc-text">Other perspectives</span></a></li></ol></li></ol></li></ol>
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